有机化学 ›› 2021, Vol. 41 ›› Issue (6): 2485-2495.DOI: 10.6023/cjoc202011023 上一篇    下一篇

研究论文

含天然苯乙烯结构的4-甲基-1,2,4-三唑-硫醚化合物的合成、除草活性及三维定量构效关系(3D-QSAR)研究

李成飞, 岑波*(), 段文贵*(), 林桂汕, 王秀, 李宝谕   

  1. 广西大学化学化工学院 南宁 530004
  • 收稿日期:2020-11-17 修回日期:2020-12-26 发布日期:2021-02-22
  • 通讯作者: 岑波, 段文贵
  • 基金资助:
    国家自然科学基金(31870556)

Synthesis, Herbicidal Activity and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Study of 4-Methyl- 1,2,4-triazole-thioether Compounds Containing Natural Styrene Structure

Chengfei Li, Bo Cen(), Wengui Duan(), Guishan Lin, Xiu Wang, Baoyu Li   

  1. College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004
  • Received:2020-11-17 Revised:2020-12-26 Published:2021-02-22
  • Contact: Bo Cen, Wengui Duan
  • Supported by:
    National Natural Science Foundation of China(31870556)

为了寻找以天然可再生资源为基础的除草剂, 设计并合成了26个新型含天然苯乙烯结构的4-甲基-1,2,4-三唑-硫醚类化合物, 并通过FTIR,1H NMR, 13C NMR, ESI-MS和元素分析等方法对其结构进行了确认. 初步的除草活性测试表明, 在质量浓度为100 µg/mL时, 大多数目标化合物对油菜胚根生长表现出良好的抑制活性, 其中8个化合物的抑制率超过81.4%, 远优于阳性对照丙炔氟草胺(抑制率63.0%); 2个化合物对稗草幼苗生长有良好的抑制活性. 比较发现, R为脂肪族取代基或吡啶环对除草活性有利. 此外, 利用CoMFA方法对R为芳族取代基的目标化合物的油菜胚根抑制活性进行了初步的三维定量构效关系(3D-QSAR)研究, 建立了合理有效的3D-QSAR模型( r2=0.996, q2=0.603).

关键词: 苯乙烯, 肉桂醛, 1,2,4-三唑硫醚, 除草活性, 三维定量构效关系(3D-QSAR)

In an attempt to search for natural renewable resource-based herbicidal agents, twenty-six novel 4-methyl-1,2,4- triazole-thioether compounds containing natural styrene structure were designed and synthesized. Their structures were confirmed by FTIR,1H NMR, 13C NMR, ESI-MS and elemental analysis. The preliminary herbicidal activity test showed that, at 100 µg/mL, most of the compounds showed good inhibitory activity against the root-growth of rape ( Brassica campestris), in which 8 compounds had inhibition rate of greater than 81.4%, implying much better herbicidal activity than that of the positive control flumioxazin with inhibition rate of 63.0%. Also, 2 compounds exhibited good inhibitory activity against the seedling-growth of barnyardgrass (Echinochloa crusgalli). It was found by comparison that aliphatic R substituents or pyridine rings were beneficial to herbicidal activity. Furthermore, a preliminary three-dimensional quantitative structure-activity relationship (3D-QSAR) study was carried out by the CoMFA method for the inhibitory activity of the target compounds with aromatic R substituents against the root-growth of rape, and a reasonable and effective 3D-QSAR model (r2=0.996, q2=0.603) has been established.

Key words: styrene, cinnamaldehyde, 1,2,4-triazole-thioether, herbicidal activity, three-dimensional quantitative structure- activity relationship (3D-QSAR)