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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (10): 1265-1267. 上一篇    下一篇

研究简报

可膨胀石墨催化的一锅法合成3,4-二氢嘧啶-2-酮衍生物

张英群*，王春，李贵深，李敬慈，刘卉敏，吴秋华   

  1. (河北农业大学理学院 保定 071001)
  • 收稿日期:2004-10-25 修回日期:2005-04-12 发布日期:2005-10-08
  • 通讯作者: 张英群

One-pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Expandable Graphite

ZHANG Ying-Qun*,WANG Chun,LI Gui-Shen
LI Jing-Ci,LIU Hui-Min,WU Qiu-Hua   

  1. (College of Science, Agricultural University of Hebei, Baoding 071001)
  • Received:2004-10-25 Revised:2005-04-12 Published:2005-10-08
  • Contact: ZHANG Ying-Qun

PDF

1452

被引次数

19

在可膨胀石墨催化下, 由芳香醛、β-酮酸酯和尿素(摩尔比1∶1∶1.5)三组分缩合制备3,4-二氢嘧啶-2-酮衍生物, 反应时间1.5～2 h, 产率可达72%～93%, 且催化剂可回收重复利用. 产物的结构经1H NMR, IR确证.

关键词: 可膨胀石墨, Biginelli反应, 3,4-二氢嘧啶-2-酮

A novel synthesis of 3,4-dihydropyrimidin-2(1H)-ones via three-component condensation of aldehydes, β-ketoester and urea with molar ratio of 1∶1∶1.5, using expansive graphite as catalyst, was described. The reaction time was 1.5～2 h, and the yield was ranged from 72% to 93%. The inexpensive catalyst could be recovered and reused without any treatment. The products were identified by 1H NMR and IR spectra.

Key words: Biginelli reaction, expandable graphite, 3,4-dihydropyrimidin-2(1H)-one