有机化学 ›› 2015, Vol. 35 ›› Issue (7): 1570-1575.DOI: 10.6023/cjoc201501012 上一篇    下一篇

研究简报

三氯化铁催化Biginelli型反应合成芳亚甲基稠环嘧啶酮

葛恬, 宋洁, 姚志刚, 徐凡   

  1. 苏州大学材料与化学化工学部 苏州 215123
  • 收稿日期:2015-01-13 修回日期:2015-02-17 发布日期:2015-03-03
  • 通讯作者: 徐凡 E-mail:xufan@suda.edu.cn
  • 基金资助:

    国家自然科学基金(Nos. 21272168, 20872106)资助项目.

Efficient Synthesis of Arylidene Heterobicyclic Pyrimidinone via Ferric Chloride Catalyzed Biginelli-Type Reaction

Ge Tian, Song Jie, Yao Zhigang, Xu Fan   

  1. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123
  • Received:2015-01-13 Revised:2015-02-17 Published:2015-03-03
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21272168, 20872106).

嘧啶酮及其官能化衍生物常具有重要生理活性, 因此该类化合物的合成受到了众多化学家的关注. 本工作以三氯化铁催化芳醛、脲(硫脲)和环戊酮的“一锅化”Biginelli-type缩合反应, 在无溶剂、无保护的条件下合成了一系列芳亚甲基稠环嘧啶酮化合物. 该方法所用催化剂经济易得, 且催化剂用量较少, 反应条件温和, 产率较高.

关键词: 三氯化铁, 催化, Biginelli反应, 芳亚甲基稠环嘧啶酮

Pyrimidinone and its functionalized derivatives are known to possess a broad-spectrum of biological activities. This paper described an efficient method for the synthesis of pyrimidinones via ferric chloride catalyzed Biginelli-type condensation of aromatic aldehyde, cyclopentanone, and urea or thiourea. The reactions produce a series of arylidene heterobicyclic pyrimidinones in moderate to excellent yields under solvent-free conditions.

Key words: ferric chloride, catalysis, Biginelli reaction, arylidene heterobicyclic pyrimidinone