[1] Kappe, C. O. QSAR Comb. Sci. 2003, 22, 630.[2] Kaan, H. Y. K.; Ulaganathan, V. R. O.; Prokopcov, H.; Dallinger, D.; Kappe, C. O.; Kozielski, J. F. J. Med. Chem. 2010, 5, 1560.[3] Kappe, C. O. Eur. J. Med. Chem. 2000, 35, 1043.[4] Kappe, C. O.; Stadler, A. Microwaves in Organic and Medicinal Chemistry, Wiley-VCH, Weinheim, 2005, p. 410.[5] Nagarathnam, D.; Miao, S. W.; Lagu, B.; Chiu, G.; Fang, J.; Murali, D. T. G.; Zhang, J. J. Med. Chem. 1999, 42, 4764.[6] Murali, D. T. G.; Nagarathnam, D.; Marzabadi, M. R.; Wong, W. C.; Miao, S. W.; Zhang, F. Q. J. Med. Chem. 1999, 42, 4778.[7] Lagu, B.; Tian, D.; Nagarathnam, D.; Marzabadi, M. R.; Dhar, T. G. M.; Jeon, Y. T. J. Med. Chem. 1999, 42, 4794.[8] Wong, W. C.; Sun, W.; Lagu, B.; Tian D.; Marzabadi, M. R.; Zhang, F.; Nagarathnam, D.; Miao, S. W.; Wetzel, J. M.; Peng, J. J. Med. Chem. 1999, 42, 4804.[9] Lagu, B.; Tian, D.; Chiu, G.; Nagarathnam, D.; Fang, J.; Shen, Q.; Forray, C.; Ransom, R. W.; Chang, R. S. L.; Vyas, K. P. Bioorg. Med. Chem. Lett. 2000, 10, 175. [10] Barrow, J. C.; Glass, K. L.; Selnick, H. G.; Freidinger, R. M.; Chang, R. S .L.; O'Malley, S. S.; Woyden, C. Bioorg. Med. Chem. Lett. 2000, 10, 1917.[11] Mayer, T. U.; Kapoor, T. M.; Haggarty, S. J.; King, R. W.; Schreiber, S. L.; Mitchison, T. J. Science 1999, 286, 971.[12] Deres, K.; Schröder, C. H.; Paessens, A.; Goldmann, S.; Hacker, H. J.; Weber, O.; Kraemer, T.; Niewoehner, U.; Pleiss, U. Science 2003, 299, 893.[13] Heys, L.; Moore, C. G.; Murphy, P. J. Chem. Soc. Rev. 2000, 29, 57.[14] Barluenga, J.; Tomas, M.; Rubio, V.; Gotor, V. J. Chem. Soc. 1995, 16, 1369.[15] Aron, Z. D.; Overman, L. E. Chem. Commun. 2004, 34, 253.[16] Wang, D.-C.; Yuan, T.-F.; Yang, X.-N.; Qu, G.-R. Chin. J. Org. Chem. 2007, 27, 1034 (in Chinese).(王东超, 袁腾飞, 杨西宁, 渠桂荣, 有机化学, 2007, 27, 1034.)[17] Sun, S.-Q.; Li, Y.-J.; Zhang, Z.-G.; Yu, S.-J.; Sun, P.; Zhou, X.-X. J. Liaoning Normal Univ.2011, 34, 4 (in Chinese).(孙淑琴, 李英俊, 张治广, 于世钧, 孙鹏, 周晓霞, 辽宁师范大学学报, 2011, 34, 4.)[18] Stadler, A.; Kappe, C. O. J. Chem. Soc., Perkin. Trans. 2 2000, 1363.[19] Fu, N.-Y.; Yuan, Y.-F.; Pang, M.-L.; Wei, B.; Guo, J. Chem. J. Chin. Univ. 2003, 24, 79 (in Chinese).(傅南雁, 袁耀锋, 庞美丽, 卫兵, 郭建, 高等化学学报, 2003, 24, 79.)[20] Shutalev, A. D.; Sivova, N. V. Chem. Heterocycl. Compd. 1988, 34, 848.[21] Liu, Y.; Liu, X.-L.; Huang, G.-W.; Wang, Q. J. Jiangxi Univ. 2010, 34, 4 (in Chinese).(刘园, 刘晓玲, 黄国文, 王清, 江西师范大学学报, 2010, 34, 4.)[22] Peng, J.; Deng, Y. Chin. J. Org. Chem. 2002, 22, 71 (in Chinese).(彭建, 邓宇, 有机化学, 2002, 22, 71.)[23] Ma, J.-G.; Zhang, J.-M.; Zhou, J.-H. Shandong Sci. 2011, 24, 22 (in Chinese).(马金广, 张纪明, 周建华, 山东科学, 2011, 24, 22.)[24] Crystal data for 6-Methyl-5-(4-methylbenzoyl)-4-(3-nitrophenyl)- 3,4-dihydropyrimidin-2(1H)-one (12). m.p. 217.1~220.3℃. C19H17N3O4, Mr=351.36, triclinic, P-1, a=7.381(3) Å, α=65.390(5)°, b=11.938(4) Å, β=79.186(5)°, c=13.176(5) Å, γ=81.968(5)°, V=1034.4(6) A3, Z=21, Dcalcd=1.270 mg/m-3, T=298(2) K, radiation=0.71073 Å, final R indices[I>2σ(I)], R1=0.0755, wR2=0.1728, R indices (all data), R1=0.1428, wR2=0.2038, for all data reflections collected/unique 5422/3792[R(int)=0.0278], GOF=1.016. Diffraction data were measured on a Siemens 4 Circle single-crystal X-ray diffractometer. |