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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (01): 120-122. 上一篇    下一篇

研究简报

二丁基氧化锡脱脂肪族糖苷乙酰保护基的研究

王少敏*,a,b，李娟a,b，李华雨a，刘宏民b，李雯c   

  1. (a郑州大学化学系 郑州 450052)
    (b郑州大学新药研究开发中心 郑州 450052)
    (c郑州大学化工学院 郑州 450052)
  • 收稿日期:2007-02-07 修回日期:1900-01-01 发布日期:2008-01-23
  • 通讯作者: 王少敏

Deacetylation Method of Aliphatic Glycosides Catalyzed byDibutyltin Oxide

WANG Shao-Min*,a,b, LI Juan a, LI Hua-Yu a, LIU Hong-Minb, LI Wenc   

  1. (a Department of Chemistry, Zhengzhou University, Zhengzhou 450052)
    (b New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450052)
    (c School of Chemical Engineering, Zhengzhou University, Zhengzhou 450052)
  • Received:2007-02-07 Revised:1900-01-01 Published:2008-01-23
  • Contact: WANG Shao-Min

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研究了以二丁基氧化锡为催化剂, 在甲醇溶剂中, 含有不同官能团的脂肪族糖苷的脱乙酰保护基反应. 结果表明采用该方法可以选择地得到糖上全部或部分脱乙酰保护基产物, 并且脱保护产物的立体构型保持, 没有分解现象发生. 该方法具有操作简单、反应条件温和、产率高等特点.

关键词: 二丁基氧化锡, 脱乙酰作用, 立体选择性, 脂肪族糖苷

Deprotection of acetylated glycoside in the presence of catalytic amounts of dibutyltin oxide in methanol was described. Acetyl groups in these glycosides could be smoothly and selectively deprotected in good yields without obvious isomerizations or degradations of the sugar part under the reaction conditions. Compared to the previous methods, this new method has the advantages of simple procedure, mild condi-tions and high yields.

Key words: deacetylation, dibutyltin oxide, regioselectivity, aliphatic glycoside