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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (05): 776-779. 上一篇    下一篇

研究简报

新型手性N,P配体的合成及其在烯丙基化中的应用

王其军a ; 高永光a ; 孟祥燕a ; 李新生*,a,b; 徐东成a,b   

  1. (a浙江师范大学化学与生命科学学院 金华 321004)
    (b浙江师范大学物理化学研究所 浙江省固体表面反应化学重点实验室 金华 321004)
  • 收稿日期:2008-10-14 修回日期:2008-12-08 发布日期:2009-05-20
  • 通讯作者: 李新生

Synthesis of New Chiral N,P Ligands and Their Application to Allylation

Wang, Qijuna ; Gao, Yongguang a ; Meng, Xiangyan a;
Li, Xinsheng*,a,b ; Xu, Dongcheng a,b
  

  1. (a Department of Chemistry and Life Science, Zhejiang Normal University, Jinhua 321004)
    (b Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Institute of Physical Chemistry, Zhejiang
    Normal University, Jinhua 321004)
  • Received:2008-10-14 Revised:2008-12-08 Published:2009-05-20
  • Contact: Li, Xinsheng

PDF

1225

被引次数

2

以手性5,6,7,8-四氢-8-喹啉醇为原料合成了新型手性N,P配体, 并将该配体应用于钯催化的1,3-二苯基-2-烯丙基乙酸酯的不对称烯丙基化反应, 得到100%的取代产物, 对映体过量达到73% ee.

关键词: 烯丙基化, 不对称催化
, N,P配体

Novel chiral N,P ligands derived from chiral 5,6,7,8-tetrahydro-8-quinolinol have been prepared and examined in the palladium-catalyzed enantioselective allylation using 1,3-diphenyl-2-propenyl acetate, which afforded the allyl substituted products in high yields (100%) and good enantioselectivities (up to 73% ee).

Key words: allylation, asymmetric catalys, N,P ligand