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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (11): 1930-1933. 上一篇    下一篇

研究简报

N-(4-取代苯基-噻唑-2-基)香豆素类亚胺化合物的合成及抑菌活性研究

袁明月1，张冬暖1，闫红飞2，刘伟华1，李德富1，张英群*1   

  1. (1河北农业大学理学院 保定 071001)
    (2河北农业大学植物保护学院 保定 071001)
  • 收稿日期:2011-04-29 修回日期:2011-06-17 发布日期:2011-07-14
  • 通讯作者: 张英群 E-mail:yingqun0203@163.com

Synthesis and Antibacterial Activity of N-(4-Substituted phenylthiazol-2-yl)coumarins

Yuan Mingyue1 Zhang Dongnuan1 Yan Hongfei2 Liu Weihua1 Li Defu1 Zhang Yingqun*1   

  1. (1 College of Science, Agricultural University of Hebei, Baoding 071001)
    (2 College of Plant Protection, Agricultural University of Hebei, Baoding 071001)
  • Received:2011-04-29 Revised:2011-06-17 Published:2011-07-14

PDF

1197

被引次数

22

由含不同取代基的水杨醛与乙酰乙酸乙酯在哌啶存在下反应, 得到乙酰基香豆素中间体, 再与氨基硫脲缩合, 得到含香豆素基的缩氨基硫脲化合物, 继而与α-溴代芳基酮发生缩合反应, 合成了9个未见报道的新的N-(4-取代苯 基-噻唑-2-基)香豆素类亚胺化合物, 其结构用IR, 1H NMR和HRMS进行了确证, 初步生物活性测定实验证明部分目标化合物具有良好的抑菌活性.

关键词: 缩氨基硫脲, N-(4-取代苯基-噻唑-2-基)香豆素类亚胺化合物, 抑菌活性, 合成

Nine new N-(4-substituted phenylthiazol-2-yl)coumarins were synthesized via the condensation of aminothiourea with acetyl coumarin intermediates, which were generated by the reaction of substituted salicyladenydes with ethyl acetoacetate, and sequeutial reaction with α-bromoarylketones. These compounds exhibit good antimicrobial activities. The structures of the products were established by IR, 1H NMR and HRMS techniques.

Key words: thiosemicarbazone, N-(4-substituted phenylthiazol-2-yl) coumarins, antibacterial activity, synthesis