有机化学 ›› 2002, Vol. 22 ›› Issue (1): 64-66. 上一篇    下一篇

研究论文

二烷基胺基锂对α-芳族酮酸手性钛盐的不对称还原反应

段新方;尹承烈   

  1. 北京师范大学化学系.北京(100875)
  • 发布日期:2002-01-25

Asymmetric reduction of chiral titanium complexes of α-keto aromatic acids with lithium dialkyl amides

Duan Xinfang;Yin Chenglie   

  1. Beijing Normal Univ., Dept of Chem..Beijing(100875)
  • Published:2002-01-25

将手性配体通过交换反应引入α-芳族酮酸钛盐,以二烷基胺基锂为还原剂进行不对称还原反应得到α-羟基羧酸,对映体过量率在8.5%~24.9%之间。

关键词: 羟基羧酸P, 有机锂化合物, 锂试剂, 有机钛化合物, 芳香族化合物, 酮酸, 不对称反应, 还原反应

Chiral titanium complexes of α-keto aromatic acids(2), obtained by introducing chiral alkoxyligands into titanium complexes of the keto acids, were reduced by lithium dialkyl amides(3) yielding the corresponding mandelic acids in 8.3 to 24.9% ee.

Key words: HYDROXYCARBOXYLIC ACIDS P, ORGANO LITHIUM COMPOUNDS, LITHIUM REAGENT, ORGANOTITANIUM COMPOUNDS, AROMATIC COMPOUNDS, KETONE ACID, REDUCTION REACTION

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