有机化学 ›› 2014, Vol. 34 ›› Issue (1): 36-53.DOI: 10.6023/cjoc201308012 上一篇    下一篇

综述与进展

可离去和/或可修饰导向基团辅助的C—H键官能化反应研究进展

张巍, 张家慧, 刘运奎   

  1. 浙江工业大学化学工程与材料学院 绿色化学技术国家重点实验室培育基地 杭州 310014
  • 收稿日期:2013-08-10 修回日期:2013-09-26 出版日期:2014-01-25 发布日期:2013-09-30
  • 通讯作者: 刘运奎 E-mail:ykuiliu@zjut.edu.cn
  • 基金资助:

    国家自然科学基金(No. 21172197);浙江省自然科学基金(No. Y4100201)和浙江省科技厅(No. 2011R09002-09)资助项目.

Recent Advances in C—H Functionalizations Assisted by Removable and/or Modifiable Directing Groups

Zhang Wei, Zhang Jiahui, Liu Yunkui   

  1. State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014
  • Received:2013-08-10 Revised:2013-09-26 Online:2014-01-25 Published:2013-09-30
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21172197), the Natural Science Foundation of Zhejiang Province (No. Y4100201), the Foundation of Science and Technology Department of Zhejiang Province (No. 2011R09002-09).

过渡金属催化的导向基团辅助的C—H键官能团化反应是当前有机化学的研究热点之一. 近年来,利用可离去和/或可修饰导向基团进行C—H键官能团化反应正受到化学家的特别关注并且发展迅速. 借助可离去或可修饰导向基团,不但能够大大扩展可利用的碳氢底物,而且对于快速构建分子多样性具有重要作用. 作者按不同杂原子(氮、氧、硫、硅等)导向基团进行分类,全面综述了近年来关于可离去和/或可修饰导向基团辅助的各种C—H键官能团化反应的研究进展及合成应用. 最后,对该领域所存在的问题和局限性进行了总结,并对今后的发展方向作了展望.

关键词: 导向基团, C—H键官能化, 过渡金属催化, 分子多样性

Transition-metal catalyzed chelation-assisted C—H bond functionalization is one of hot topics in current organic chemistry. Recently, using removable and/or modifiable directing groups for C—H bond functionalizations has being received specially attention and developed rapidly. By taking advantage of removable and/or modifiable directing groups, it not only greatly expands the scope of substrates for C—H fuctionalization, but also plays important roles in rapid construction of molecule diversity. Based on the classification according to different hetero-atom (N, O, S, and Si) donors, this review presents the state of the art in design of removable and/or modifiable directing groups for transition-metal catalyzed C—H functionalizations and their application in construction of molecule diversity. Finally, the existing problems and limitations of this field are summarized, and the outlook of the area is also prospected.

Key words: directing group, C—H bond functionalization, transition-metal catalysis, molecule diversity