双环吡咯酮类化合物的简便合成

doi:10.6023/cjoc201604004

有机化学 ›› 2016, Vol. 36 ›› Issue (10): 2437-2441.DOI: 10.6023/cjoc201604004 上一篇下一篇

研究论文

双环吡咯酮类化合物的简便合成

孔令斌, 杨瑞霞, 杜璇璇, 严胜骄, 林军

云南大学化学科学与工程学院教育部自然资源药物化学重点实验室昆明 650091

收稿日期:2016-04-03 修回日期:2016-05-13 发布日期:2016-06-02
通讯作者: 严胜骄,E-mail:yansj@ynu.edu.cn;林军,E-mail:linjun@ynu.edu.cn E-mail:yansj@ynu.edu.cn;linjun@ynu.edu.cn
基金资助:
国家自然科学基金（Nos.U1202221，21362042，21662042）、云南省后备人才（No.2012HB001）和云南大学青年英才计划（No.XT412003）资助项目.

Simple Synthesis of Bicyclic Pyrrole Ketone Compounds

Kong Lingbin, Yang Ruixia, Du Xuanxuan, Yan Shengjiao, Lin Jun

School of Chemical Science And Technology, Yunnan University, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Kunming 650091

Received:2016-04-03 Revised:2016-05-13 Published:2016-06-02
Supported by:
Project supported by the National Natural Science Foundation of China (Nos.U1202221, 21362042, 21662042), the Talent Found in Yunnan Province (No.2012HB001), and the Excellent Young Talents in Yunnan University (No.XT412003).

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摘要/Abstract

建立了一锅法合成双环吡咯酮化合物的方法.该方法以杂环烯酮缩胺1为合成砌块，在1，4-二氧六环溶剂中，三乙胺作碱，与乙二醛在50℃下反应，一步法关环合成了双环吡咯酮类化合物3a~3i.该方法具有合成路线简洁、后处理简单、原料易得、产率高和操作简便等优点.

关键词: 双环吡咯酮, 杂环烯酮缩胺, 乙二醛

In this article, a one-pot protocol was established for the synthesis of bicyclic pyrrole ketone compounds. This method based on the building blocks of heterocyclic ketene aminals 1, which reacted with oxalaldehyde 2 in 1,4-dioxane at 50℃ and triethylamine as base. As a result, a series of bicyclic pyrrole ketone compounds 3a~3i have been synthesized. This reaction has some advantages such as simple synthetic route, readily available starting materials, high yields and simple work-up procedures.

Key words: bicyclic pyrrole ketone, heterocyclic ketene aminals, oxalaldehyde

引用此文

孔令斌, 杨瑞霞, 杜璇璇, 严胜骄, 林军. 双环吡咯酮类化合物的简便合成[J]. 有机化学, 2016, 36(10): 2437-2441.

Kong Lingbin, Yang Ruixia, Du Xuanxuan, Yan Shengjiao, Lin Jun. Simple Synthesis of Bicyclic Pyrrole Ketone Compounds[J]. Chin. J. Org. Chem., 2016, 36(10): 2437-2441.

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双环吡咯酮类化合物的简便合成

Simple Synthesis of Bicyclic Pyrrole Ketone Compounds

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