有机化学 ›› 2015, Vol. 35 ›› Issue (12): 2559-2567.DOI: 10.6023/cjoc201507005 上一篇    下一篇

研究论文

氯化铜促进的吲哚的傅-克羟烷基化反应

展震, 张国尧, 程旭, 吕光辉, 郑阳, 海俐, 吴勇   

  1. 四川大学华西药学院 成都 610041
  • 收稿日期:2015-07-04 修回日期:2015-08-22 发布日期:2015-08-26
  • 通讯作者: 海俐, 吴勇 E-mail:smile@scu.edu.cn;wyong@scu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos. 81373259, 81573286)资助项目.

CuCl2-Promoted Friedel-Crafts Hydroxyalkylations of Indoles

Zhan Zhen, Zhang Guoyao, Cheng Xu, Lü Guanghui, Zheng Yang, Hai Li, Wu Yong   

  1. West China School of Pharmacy, Sichuan University, Chengdu 610041
  • Received:2015-07-04 Revised:2015-08-22 Published:2015-08-26
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 81373259, 81573286).

探索了氯化铜促进下, 以1,4-二氧六环为溶剂, 在室温条件下, 通过芳基乙二醛和吲哚的傅-克羟烷基化反应, 合成吲哚基-α-酮醇的方法. 该方法具有高效、环保、成本低、操作简便等特点.

关键词: 路易斯酸, 傅-克羟烷基化, 芳基乙二醛, 吲哚

An Friedel-Crafts hydroxyalkylations reaction was explored for the synthesis of indolyl α-acyloins by treating arylglyoxals, indoles and copper chloride at room temperature in 1,4-dioxane. The method is highly efficient, environmental, low cost and concise manipulation.

Key words: Lewis acid, Friedel-Crafts hydroxyalkylations, arylglyoxals, indoles