有机化学 ›› 2016, Vol. 36 ›› Issue (11): 2723-2728.DOI: 10.6023/cjoc201603007 上一篇    下一篇

研究简报

苯基萘类木脂素内酯的化学合成

孟瑾, 杜利月, 郭留城   

  1. 漯河医学高等专科学校药学系 河南 漯河 462002
  • 收稿日期:2016-03-06 修回日期:2016-07-21 发布日期:2016-08-10
  • 通讯作者: 孟瑾 E-mail:mz_511310@163.com

Synthesis of Arylnaphthalene Lignan Lactones

Meng Jin, Du Liyue, Guo Liucheng   

  1. Department of Pharmacy, Luohe Medical College, Luohe, Henan 462002
  • Received:2016-03-06 Revised:2016-07-21 Published:2016-08-10

苯基萘类木脂素内酯是一类广泛分布于植物界的含有苯基萘骨架的天然产物.这些天然产物拥有广泛的生物活性,从而引起了人们的高度重视,成为近年来较为活跃的研究领域之一.报道了一条合成此类化合物的路线,以香草酸为起始原料,以Diels-Alder反应和Suzuki-Miyaura偶联反应构筑α-苯基萘骨架,再经Fetizon氧化等8步反应实现了Justicidin B等六个天然产物的合成.

关键词: 苯基萘类木脂素内酯, Diels-Alder反应, Suzuki-Miyaura偶联, Fetizon氧化

Arylnaphthalene lignan lactones, widely distributed in plants, are a class of natural products containing the phenyl-naphthyl skeleton. These compounds have attracted considerable attention of many scientists for decades because of their wide biological activities. In this study, a convenient method is presented for the multiple parallel synthesis of arylnaphthalene lignans. With vanillic acid as starting material, six arylnaphthalene nature products were prepared in the process with 8 steps, via Diels-Alder reaction, Suzuki reaction and Fetizon oxidation as the key reactions.

Key words: Arylnaphthalene lignan lactones, Diels-Alder reaction, Suzuki-Miyaura coupling, Fetizon oxidation