Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (02): 368-375 .DOI: 10.6023/cjoc1107031 Previous Articles     Next Articles

Articles

红紫素-18 的胺解反应及其叶绿素类二氢卟吩衍生物的合成

王朋a, 杨泽a, 李家柱b, 姚楠楠b, 王进军a,b   

  1. a 烟台大学化学化工学院 烟台 264005;
    b 烟台大学药学院 烟台 264005
  • 收稿日期:2011-07-03 修回日期:2011-09-15 出版日期:2012-02-25 发布日期:2012-03-09
  • 通讯作者: 王进军 E-mail:wjj1955@163.com
  • 基金资助:

    山东省自然科学基金(No. Y2008B49)资助项目.

Aminolysis Reaction of Purpurin-18 and Synthesis of Chlorin Derivatives Related to Chlorophyll

Wang Penga, Yang Zea, Li Jazhub, Yao Nannanb, Wang Jinjuna,b   

  1. a College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005;
    b Pharmacy College, Yantai University, Yantai 264005
  • Received:2011-07-03 Revised:2011-09-15 Online:2012-02-25 Published:2012-03-09
  • Supported by:

    Project supported by the Natural Science Foundation of Shandong Province of China (No. Y2008B49).

The aminolysis of purpurin-18 with aliphatic amines or aromatic amines was carried out by reflux and microwave assisted methods to obtain mono-amidated, di-amidated and carbonyl-imidizated products. The chemical modifications of purpurin-18 imides along their N21-NM23 axis produced the mixtures of purpurin-18 imides possessing atropisomeric and anomeric characteritics. The structures of new chlorophyll derivatives were characterized by UV, IR, 1H NMR, MS techniques and elemental analysis. The possible mechanisms about aminization reactions were tentatively proposed.

Key words: chlorophyll-a, purpurin-18, amination, purpurin-18 imide, synthesis