Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (01): 169-173.DOI: 10.6023/cjoc1107042 Previous Articles     Next Articles



肖克毅a, 戴亚b, 石万棋c, 李剑忠c, 李颖a, 尹述凡a   

  1. a 四川大学化学学院 成都 610046;
    b 卷烟减害降焦四川省重点实验室 川渝中烟工业公司技术中心 成都 610000;
    c 四川国康药业有限公司 成都 610041
  • 收稿日期:2011-07-04 修回日期:2011-09-05 发布日期:2011-09-20
  • 通讯作者: 尹述凡;;

Synthesis and Antitumor Activities of the Diacid Solanesyl 5-Fluorouracil Esters Derivatives

Xiao Keyia, Dai Yab, Shi Wanqic, Li Jianzhongc, Li Yinga, Yin Shufana   

  1. a School of Chemistry, Sichuan University, Chengdu 610064;
    b Harmful Components and Tar Reduction in Cigarette Sichuan Key Laboratory, Technical Research Center Chuanyu Branch of China Tobacco Corporation, Chengdu 610000;
    c Sichuan Guokang Pharmaceutical Company Limited, Chengdu 610041
  • Received:2011-07-04 Revised:2011-09-05 Published:2011-09-20
  • Contact: Yin Shufan;;

Twelve diacid solanesyl tegafur esters were synthesized by the reaction of solanesol with four acid anhydrides and N-alkoxy-tegafur. Their chemical structures were confirmed by IR, 1H NMR and MS techniques. The preliminary bioassay results show that the target compounds possess antitumor activities to some extent.

Key words: solanesol, tegafur, synthesis, antitumor activity