Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (01): 13-18.DOI: 10.6023/cjoc114224 Previous Articles     Next Articles


不对称Kabachnik-Fields 反应合成研究进展

万德慧, 吴明书, 马静雅   

  1. 海南师范大学化学与化工学院 热带药用植物化学省部共建重点实验室 海口 570000
  • 收稿日期:2011-04-22 修回日期:2011-08-15 发布日期:2011-09-05
  • 通讯作者: 万德慧
  • 基金资助:

    国家自然科学基金(No. 21162008)资助项目.

Recent Progress in Asymmetric Synthesis of Kabachnik-Fields Reaction

Wan Dehui, Wu Mingshu, Ma Jingya   

  1. Key Laboratory of Tropical Medicinal Plant Chemistry of the Ministry of Education and Hainan Province, College of Chemistry & Chemical Engineering, Hainan Normal University, Haikou 571158
  • Received:2011-04-22 Revised:2011-08-15 Published:2011-09-05
  • Contact: DeHui WAN
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21162008).

Asymmetric three-component Kabachnik-Field reaction for the stereoselective synthesis of optically active α-amino phosphonates has been received considerable attention due to their great intrinsic advantages as well as their applications in drug discovery. This review covers recent progress on asymmetric three-component Kabachnik-Field reaction including the chiral catalysts and optical active substrate induction approaches to chiral α-aminoalkylphosphonic acid derivatives. The influence of the chiral catalysts and reaction substrate configuration on the reaction stereoselectivity is the major focus. It elicits issues and perspectives of asymmetric three-component Kabachnik-Field reaction in the end.

Key words: Kabachnik-Fields reaction, asymmetric synthesis, chiral α-aminoalkylphosphonic acid