Recent Progresses in Total Synthesis of (+)-Biotin

doi:10.6023/cjoc1203041

Abstract

(+)-Biotin is one of the B vitamins. The study on total synthesis of (+)-biotin is an incessant pursuit since it was discovered half century ago. During the past ten years great advances in this field have been made. The synthetic approaches toward the target molecule can be classified into two series: the enatioselective syntheses and the stereospecific syntheses. In former approach, modification of the already existed Hoffmann-La-Roche’s lactone-thiolactone approach was further developed in diversified ways, especially the great advance in asymmetric synthesis of the chiral framework of (+)-biotin, which had been put into industrial practice successfully; in terms of the latter approach, L-cysteine or cystine can be regarded as more logical starting materials. Enriched by a plenty of ingenious novel strategies and tactics, this approach evolved more facile and practical than before.

Key words: (+)-biotin, total synthesis, progress

Cite this article

Zhong Zheng, Wu Xuefen, Chen Fener. Recent Progresses in Total Synthesis of (+)-Biotin[J]. Chin. J. Org. Chem., 2012, 32(10): 1792-1802.

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(+)-生物素全合成研究新进展