Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (01): 169-173.DOI: 10.6023/cjoc201208037 Previous Articles     Next Articles



赵育, 倪春燕, 张虞婷, 朱俐   

  1. 南通大学航海医学研究所 南通 226001
  • 收稿日期:2012-08-31 修回日期:2012-09-24 发布日期:2012-10-09
  • 通讯作者: 朱俐
  • 基金资助:

    江苏省自然科学基金(No. BK2011390);江苏省高校优势学科(PAPD)资助项目.

Synthesis and Antiproliferatory Activity of Novel Diphyllin Hydroxamic Acid and Mercaptan Derivatives

Zhao Yu, Ni Chunyan, Zhang Yuting, Zhu Li   

  1. Institute of Nautical Medicine, Nantong University, Nantong 226001
  • Received:2012-08-31 Revised:2012-09-24 Published:2012-10-09
  • Supported by:

    Project supported by the Natural Science Foundation of Jiangsu Province (No. BK2011390) and the Priority Academic Program Development of Jiangsu Higher Education Instititutions (PAPD).

Seven novel diphyllin derivatives have been synthesized by incorporating histone deacetylase inhibitory functional groups into diphyllin. The structures were confirmed by 1H NMR, 13C NMR and HRMS. Their antiproliferative activity against three human cancer cell lines was investigated by methyl thiazolyl tetrazoliym (MTT) assay.

Key words: diphyllin, histone deacetylase inhibitors, antitumor, synthesis