Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (05): 1108-1112.DOI: 10.6023/cjoc201210019 Previous Articles     Next Articles



袁明月a, 刘伟华a, 张英群a, 闫红飞b, 张冬暖a, 刘卉闵a, 王建平c   

  1. a 河北农业大学理学院 保定 071001;
    b 河北农业大学植物保护学院 保定 071001;
    c 河北农业大学动物科技学院 保定 071001
  • 收稿日期:2012-10-17 修回日期:2012-12-21 发布日期:2013-01-07
  • 通讯作者: 张英群,
  • 基金资助:

    河北省教育厅计划项目(No. 2009435)、河北农业大学非生命学科和新兴学科科研发展基金(No. 2009020)资助项目.

Synthesis and Biological Activity of N-[4-(Coumarin-3-yl)thiazol-2-yl] Aromatic Aldehyde Hydrazones under Microwave Irradiation

Yuan Mingyuea, Liu Weihuaa, Zhang Yingquna, Yan Hongfeib, Zhang Dongnuana, Liu Huimina, Wang Jianpingc   

  1. a College of Science, Agricultural University of Hebei, Baoding 071001;
    b College of Plant Protection, Agricultural University of Hebei, Baoding 071001;
    c College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071001
  • Received:2012-10-17 Revised:2012-12-21 Published:2013-01-07
  • Supported by:

    Project supported by the Foundation of Hebei Educational Committee (No. 2009435), the Non-life disciplines and Emerging Disciplines Foundation of Hebei Agricultural University (No. 2009020).

A series of N-[4-(coumarin-3-yl)thiazol-2-yl] aromatic aldehyde hydrazones have been prepared via the condensation of thiosemicarbazone with α-bromoacetyl coumarin, using microwave heating methodology. The yield was ranged from 69% to 97%. Their chemical structures have been confirmed by means of IR, 1H NMR and HRMS. Bioassay of the title compounds indicated that some of them exhibited good antibacterial activity.

Key words: N-[(4-(coumarin-3-yl)thiazol-2-yl) aromatic aldehyde hydrazones, synthesis, microwave, antibacterial activity