Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (10): 2080-2097.DOI: 10.6023/cjoc201304007 Previous Articles     Next Articles



杨绪红, 曹晓蓓, 金小红, 吴鸣虎   

  1. 湖北科技学院核技术与化学生物学院 咸宁 437100
  • 收稿日期:2013-04-03 修回日期:2013-05-07 出版日期:2013-10-25 发布日期:2013-05-13
  • 通讯作者: 吴鸣虎
  • 基金资助:

    国家自然科学基金(No. 21202136)资助项目

Progress in Synthesis of Pyrazolopyrimidinone

Yang Xuhong, Cao Xiaobei, Jin Xiaohong, Wu Minghu   

  1. Faculty of Nuclear Technology & Chemistry and Biology, Hubei University of Science and Technology, Xianning 437100
  • Received:2013-04-03 Revised:2013-05-07 Online:2013-10-25 Published:2013-05-13
  • Supported by:

    Project supported by the National Natural Science Fundation of China (No. 21202136).

Pyrazolopyrimidinone compounds are widely found in nature. Since the first pyrazolopyrimidinone was synthesized in 1888, synthesis and application of pyrazolopyrimidinones have been more and more active. Some pyrazolopyrimidinones are applied to the treatment of commom diseases, and are called the crown jewels in drug discovery history. For more than one century, various synthetic methodologies concerning pyrazolopyrimidinone have been developed. However, no specific review about pyrazolopyrimidinones was present. This review comments the synthesis of pyrazolopyrimidinone from the point of view of the synthetic methodology.

Key words: 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one, 1H-pyrazolo[3,4-d]pyrimidin-6(7H)-one, 1H-pyrazolo[4,3-d]pyrimidin-5(4H)-one, 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, pyrazolopyrimidinone, synthesis