Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (4): 613-629.DOI: 10.6023/cjoc201310052 Previous Articles     Next Articles



万福贤a, 俞开潮b   

  1. a 山东农业大学化学与材料科学学院 泰安 271018;
    b 华中科技大学化学与化工学院 武汉 430074
  • 收稿日期:2013-10-31 修回日期:2013-12-18 发布日期:2013-12-27
  • 通讯作者: 俞开潮
  • 基金资助:

    国家自然科学基金(No. 20675033)和山东省科技发展计划(No. 2013CEX2019)资助项目

Recent Progress in the Synthesis of Bifunctional Diethylenetriamine-pentaacetic Acid Derivatives Ligand for Magnetic Resonance Imaging Contrast Agent

Wan Fuxiana, Yu Kaichaob   

  1. a College of Chemistry and Material Science, Shan Dong Agricultural University, Taian 271018;
    b School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074
  • Received:2013-10-31 Revised:2013-12-18 Published:2013-12-27
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 20675033) and the Science and Technology Development of Shandong Province (No. 2013CEX2019).

Diethylenetriaminepentaacetic acid (DTPA) and its derivatives have been used in chemistry, biology, medicine and many other fields due to their coordination properties, especially, used as magnetic resonance imaging (MRI) contrast agent. Bifunctional-DTPA ligand can be easily and readily linked to various biomolecules. It is of primary importance for the development high relaxation efficiency and/or targeted MRI contrast agents, but the synthesis of bifunctional-DTPA ligand is rather difficult. In this review, various synthetic methods for synthesizing these compounds are summarized.

Key words: magnetic resonance imaging, DTPA, gadolinium-complexes, bifunctional chelator, synthesis