Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (11): 2202-2216.DOI: 10.6023/cjoc201405010 Previous Articles     Next Articles


刘亚君, 郭翔海, 白鹏   

  1. 天津大学化工学院 系统生物工程教育部重点实验室 天津 300072
  • 收稿日期:2014-05-07 修回日期:2014-06-10 发布日期:2014-07-03
  • 通讯作者: 郭翔海,
  • 基金资助:


Recent Progress in the Syntheses of Carbocyclic Nucleosides

Liu Yajun, Guo Xianghai, Bai Peng   

  1. Key Laboratory of Systems Bioengineering, Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072
  • Received:2014-05-07 Revised:2014-06-10 Published:2014-07-03
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.21202116).

Carbocyclic nucleosides are nucleoside analogues whose furanose rings are substituted by carbocycles. As analogues, many carbocyclic nucleosides show good antiviral or antitumor activities. Also, due to the absence of a typical glycosidic bond, carbocyclic nucleosides usually exhibit more metabolic stabilities to phosphorylases and hydrolases than natural nucleosides. Therefore, medicinal chemists have focused their attention on designing and preparing new carbocyclic nucleoside analogues, in efforts to discover new more powerful and safe antiviral agents. The syntheses of carbocyclic nucleosides in the past five years classified by different types of bases are reviewed in this article, denoted as purine carbocyclic nucleosides, pyrimidine carbocyclic nucleosides and carbocyclic analogues of C-nucleosides, with an emphasis on the synthesis of purine carbocyclic nucleosides. In the end, the problems and future trends of carbocyclic nucleoside research are discussed. It is still a challenge to intelligently design and efficiently synthesize the novel carbocyclic nucleosides targeted for some special purposes.

Key words: carbocyclic nucleosides, antiviral activity, synthesis