Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (1): 144-151.DOI: 10.6023/cjoc201407014 Previous Articles     Next Articles



高文涛, 兰帅, 郑宏梅, 白仁青卓玛   

  1. 渤海大学超精细化学品研究所 锦州 121000
  • 收稿日期:2014-07-10 修回日期:2014-09-03 发布日期:2014-09-25
  • 通讯作者: 高文涛
  • 基金资助:

    国家自然科学基金(No. 21476028)和辽宁省自然科学基金(No. 20120201)资助项目.

A Facile Synthesis of Thiazole Skeleton-Containing Indole Derivatives

Gao Wentao, Lan Shuai, Zheng Hongmei, Bairenqing Zhuoma   

  1. Institute of Superfine Chemicals, Bohai University, Jinzhou 121000
  • Received:2014-07-10 Revised:2014-09-03 Published:2014-09-25
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21476028) and the Natural Science Foundation of Liaoning Province (No. 20120201).

An efficient and easy method for the synthesis of thiazole-containing indole derivatives was described, involving the condensation reaction of 5-chloroacetyloxindole with thiourea (substituted thiourea) and thioamide in the solvent of absolute ethanol via Hantzseh reaction to give the corresponding 5-(2-substituted-thiazol-4-yl)indolin-2-one (2a2k) and 5-(2-substituted-thiazol-4-yl)indolin-2-one (2l2q), respectively. The procedure has the advantages of simple operation, mild reaction conditions, and good yields. All of compounds were new and their structures were confirmed by IR, MS, P1PH NMR and P13PC NMR spectra and elemental analyses.

Key words: 5-chloroacetyloxindole, thioamide, thiourea, thiazole-containing, indole derivatives, synthesis