Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (5): 1112-1122.DOI: 10.6023/cjoc201411033 Previous Articles     Next Articles



郑国勋, 张宗昌, 康博瑞, 于瑞红, 曹永孝, 张三奇   

  1. 西安交通大学医学部 西安 710061
  • 收稿日期:2014-11-20 修回日期:2014-12-30 发布日期:2015-01-14
  • 通讯作者: 张三奇
  • 基金资助:


Synthesis and Vasodilatation of Homoisoflavones

Zheng Guoxun, Zhang Zongchang, Kang Borui, Yu Ruihong, Cao Yongxiao, Zhang Sanqi   

  1. Xi'an Jiaotong University Health Science Center, Xi'an 710061
  • Received:2014-11-20 Revised:2014-12-30 Published:2015-01-14
  • Supported by:

    Project supported by the Innovation Project on Science and Technology of Shanxi Province (No.2012KPCL03-20).

Homoisoflavones were designed as vasodilative agents on the basis of scaffold hopping. A series of homoisoflavones were synthesized from 2-acetylphenol and aromatic aldehyde via aldol condensation, hydrogenation and cyclization. The structures of title compounds were characterized by 1H NMR, MS and HRMS. The vasodilative effects of synthesized compounds were evaluated by wire myograph on isolated rat mesenteric arterial ring induced contraction with 60 mmol/L KCl. The results suggest that the title compounds are novel vasodilative agents.

Key words: homoisoflavones, synthesis, vasodilatation