Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (6): 1204-1215.DOI: 10.6023/cjoc201412012 Previous Articles     Next Articles



肖立伟, 彭晓霞, 周秋香, 寇伟, 时亚茹   

  1. 廊坊师范学院 化学与材料科学学院 廊坊 065000
  • 收稿日期:2014-12-05 修回日期:2015-02-09 发布日期:2015-02-11
  • 通讯作者: 肖立伟
  • 基金资助:

    河北省自然科学基金(No. B2013408014)和廊坊师范学院重点(No. LSLZ201402)资助项目.

Application of Multi-component Reaction in Synthesis of Multi- substituted Imidazoles

Xiao Liwei, Peng Xiaoxia, Zhou Qiuxiang, Kou Wei, Shi Yaru   

  1. Faculty of Chemistry and Material Science, Langfang Teachers University, Langfang 065000
  • Received:2014-12-05 Revised:2015-02-09 Published:2015-02-11
  • Supported by:

    Project supported by the Natural Science Foundation of Hebei Province (No. B2013408014) and the Key Foundation of Langfang Teachers University (No. LSLZ201402).

Multi substituted imidazoles including tri- and tetra-substituted imidazoles, play important roles in the field of pharmaceutical, chemical sensing and catalysis etc. Multi-component reaction (MCR), a protocol with high atom economic and reaction selectivity, has been applied widly on the synthesis of multi-substituted imidazoles. Based on different starting materials and different methods, the recent advances in the synthesis of multi-substituted imidazols via multi-component reaction are reviewed.

Key words: tri-substituted imidazoles, tetra-substituted imidazoles, multi-component reaction, heterogeneous catalysis