Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (9): 1975-1980.DOI: 10.6023/cjoc201503004 Previous Articles     Next Articles



朱继华, 郑旭东, 郭国哲, 张玉全, 仵博万   

  1. 陇东学院化学化工学院 陇东学院-氟乐邦表面活性中心 庆阳 745000
  • 收稿日期:2015-03-04 修回日期:2015-05-19 发布日期:2015-05-29
  • 通讯作者: 朱继华
  • 基金资助:

    甘肃省自然科学基金(No. 1208RJZM289)、庆阳市科技局工业支撑重点(No. KZ2014-27)资助项目.

Microwave-Assisted Synthesis of Asymmetrical 1,5-Disubstituted Carbonohydrazide and Crystal Structure

Zhu Jihua, Zheng Xudong, Guo Guozhe, Zhang Yuquan, Wu Bowan   

  1. College of Chemistry & Chemical Engineering, Longdong University-Fluobon Surfactant Engineering Technology Center, Qingyang 745000
  • Received:2015-03-04 Revised:2015-05-19 Published:2015-05-29
  • Supported by:

    Project supported by the Applied Chemistry Key Subject of Gansu Pronvince (No. GSACKS20130113).

A series of asymmetrical 1,5-disubstituted carbonohydrazides 4a~4p were synthesized by the condensation of various substituted aromatic aldehydes and 1-(2-hydroxyphenylidene)carbonohydrazide (3) under microwave irradiation at 120 ℃ and 350 W in ethanol-sulfuric acid mixture for 16~30 min. The starting materials 3 was synthesized using salicylaldehyde and carbohydrazide under water at room temperature. The new synthesized compounds were characterized by IR, 1H NMR, 13C NMR spectra and elemental analysis. Compared with the conventional heating method, this method is simple, fast, efficient and eco-friendly. This reaction is expected to be a powerful tool for the synthesis of asymmetrical Schiff bases compounds. The X-ray diffraction analysis indicates that the compound 4i belongs to monoclinic, space group P21/c.

Key words: asymmetrical 1,5-disubstituted carbonohydrazide, synthesis, characterization, microwave irradiation, crystal structure