Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (2): 393-398.DOI: 10.6023/cjoc201509011 Previous Articles     Next Articles



戴红a,b, 刘建兵a, 陶伟峰a, 苗文科a, 方建新a, 汪清民a   

  1. a 南开大学元素有机化学国家重点实验室 天津 300071;
    b 南通大学化学化工学院 南通 226019
  • 收稿日期:2015-09-08 修回日期:2015-09-30 发布日期:2015-11-03
  • 通讯作者: 戴红, 方建新;
  • 基金资助:

    国家自然科学基金(Nos. 20772068)、元素有机化学国家重点实验室开放课题(No. 201412)和南通市科技计划(Nos. CP12013002, AS2014011)资助项目

Synthesis, Crystal Structure and Biological Activity of Novel 1-(Pyridin-2-yl)-2-aryloxy-2-(1H-1,2,4-triazol-1-yl)ethanones

Dai Honga,b, Liu Jianbinga, Tao Weifenga, Miao Wenkea, Fang Jianxina, Wang Qingmina   

  1. a State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071;
    b College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
  • Received:2015-09-08 Revised:2015-09-30 Published:2015-11-03
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 20772068), the Open Project Fund of State Key Laboratory of Elemento-organic Chemistry (No. 201412), and the Science and Technology Project Fund of Nantong City (Nos. CP12013002, AS2014011)

In order to find novel triazole lead compounds, a series of new triazole derivatives containing pyridine moiety were synthesized by the introduction of the important pyridyl backbone into the molecules of triazoles. They were structurally confirmed by 1H NMR, 13C NMR, IR, MS and elemental analysis. Additionally, compound 4k was structurally characterized through X-ray single crystal diffraction method. Preliminary bioassay data showed that some of the title compounds displayed moderate fungicidal and plant growth regulatory activities.

Key words: triazole, pyridine, synthesis, bioactivity