Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (12): 2981-2985.DOI: 10.6023/cjoc201604037 Previous Articles     Next Articles



邓杰, 李爱暖, 李清寒, 丁勇, 杨学军, 陈峰   

  1. 西南民族大学化学与环境保护工程学院 成都 610041
  • 收稿日期:2016-04-18 修回日期:2016-07-19 发布日期:2016-08-22
  • 通讯作者: 李清寒
  • 基金资助:

    四川省科技厅科技支撑计划(No. 2015NZ0033)和西南民族大学大学生创新创业训练基金(No. S201510656121)资助项目.

Synthesis and Antitumor Activities of Alkyl 4-(Bis(4-fluorophenyl)-methyl)piperazine-1-carbodithioate Derivatives

Deng Jie, Li Ainuan, Li Qinghan, Ding Yong, Yang XueJun, Chen Feng   

  1. College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041
  • Received:2016-04-18 Revised:2016-07-19 Published:2016-08-22
  • Supported by:

    Project supported by the Sichuan Provincial Department of Science and Technology (No. 2015NZ0033) and the Southwest University for Nationalities Students Innovation and Entrepreneurship Training (No. S201510656121).

Thirteen new alkyl 4-(bis(4-fluorophenyl)methyl)piperazine-1-carbodithioatee derivatives were synthesized with 1-(bis(4-fluorophenyl)methyl)piperazine, substituted benzyl or alkyl bromide and methane-dithione as starting material in the presence of K3PO4. Their structures were determined by IR, MS and 1H NMR. Preliminary bioassay indicated that twelve compounds exhibited good activities against CDC25B (the inhibition rates up to 99% at the concentration of 20 μg/mL), three compounds exhibited a certain degree against Leukemia HL-60 cell (the inhibition rates up to 54.59% at the concentration of 40 μmol/L).

Key words: 1-(bis(4-fluorophenyl)methyl)piperazine, carbodithioate, organic synthesis, antitumor activity