Palladium-Catalyzed Dearomative Decarboxylative Alkynylation of Indoles with Acetylenecarboxylic Acids

doi:10.6023/cjoc201608027

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (3): 691-697.DOI: 10.6023/cjoc201608027 Previous Articles Next Articles

ARTICLE

钯催化吲哚与丙炔酸的去芳构化脱羧炔基化反应

王永刚, 刘人荣, 高建荣, 贾义霞

浙江工业大学化工学院杭州 310014

收稿日期:2016-08-26 修回日期:2016-11-15 发布日期:2016-11-22
通讯作者: 贾义霞,E-mail:yxjia@zjut.edu.cn E-mail:yxjia@zjut.edu.cn
基金资助:
国家自然科学基金基金（Nos.21372202，1522207）资助项目.

Palladium-Catalyzed Dearomative Decarboxylative Alkynylation of Indoles with Acetylenecarboxylic Acids

Wang Yonggang, Liu Renrong, Gao Jianrong, Jia Yixia

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014

Received:2016-08-26 Revised:2016-11-15 Published:2016-11-22
Contact: 10.6023/cjoc201608027 E-mail:yxjia@zjut.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21372202, 21522207).

1. Palladium-Catalyzed Dearomative Decarboxylative Alkynylation of Indoles with Acetylenecarboxylic Acids.PDF(1776KB)

Abstract

A palladium-catalyzed indole dearomative arylalkynylation via decarboxylative coupling of alkynyl carboxylic acids and alkyl-palladium intermediates has been developed, which provides a reliable approach to a serious of structural diversely 2,3-disubstituted indolines bearing vicinal tertiary and quaternary stereocenters in moderate to good yields and excellent diastereoselectivities.

Key words: homogenous catalysis, palladium, indole, dearomatization, alkynylation

Cite this article

Wang Yonggang, Liu Renrong, Gao Jianrong, Jia Yixia. Palladium-Catalyzed Dearomative Decarboxylative Alkynylation of Indoles with Acetylenecarboxylic Acids[J]. Chin. J. Org. Chem., 2017, 37(3): 691-697.

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钯催化吲哚与丙炔酸的去芳构化脱羧炔基化反应

Palladium-Catalyzed Dearomative Decarboxylative Alkynylation of Indoles with Acetylenecarboxylic Acids

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