Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (6): 1433-1442.DOI: 10.6023/cjoc201612038 Previous Articles     Next Articles



陈亮, 王保取, 赵宇澄, 严胜骄, 林军   

  1. 云南大学化学科学与工程学院 教育部自然资源药物化学重点实验室 昆明 650091
  • 收稿日期:2016-12-12 修回日期:2017-01-21 发布日期:2017-02-20
  • 通讯作者: 严胜骄,林军;
  • 基金资助:


One-Pot Synthesis of Multisubstituted Chromone-Fused Bicyclic Pyridine Compounds

Chen Liang, Wang Baoqu, Zhao Yucheng, Yan Shengjiao, Lin Jun   

  1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science andTechnology, Yunnan University, Kunming 650091
  • Received:2016-12-12 Revised:2017-01-21 Published:2017-02-20
  • Contact: 10.6023/cjoc201612038;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. U1202221, 21362042, 21262042, 21662042), the Talent Found in Yunnan Province (No. 2012HB001), and the Excellent Young Talents of Yunnan University (No. XT412003).

A concise and environment friendly route for the synthesis of multisubstituted chromone-fused bicyclic pyridine compounds via one-step reaction of chromone-3-carboxaldehyde 1 and N-benzyl nitro ketene aminals (NBNKAs, 2) in ethanol media has been developed. The targeted compounds 3 can efficiently obtain by filter without extra post-treatment. The reaction is particularly attractive due to following features: low-cost and biocompatibility solvent, mild temperature, atom economy, high yields, and potential biological activity.

Key words: environment friendly, atom economy, catalyst-free, bicyclic pyridine, neonicotinoids