Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (7): 1877-1882.DOI: 10.6023/cjoc201612048 Previous Articles     Next Articles



赵安林a, 刘姝a, 朱咏梅b, 王涛a, 罗劲a,b   

  1. a. 江西省化学生物学重点实验室 江西师范大学化学化工学院 南昌 330022;
    b. 江西师范大学分析测试中心 南昌 330022
  • 收稿日期:2019-12-19 修回日期:2017-02-19 发布日期:2017-03-03
  • 通讯作者: 王涛, 罗劲;
  • 基金资助:


Designed, Synthesis and Herbicidal Activity of Novel 2-Alkylthio-thieno[2,3-d]pyrimidin-4-ones

Zhao Anlina, Liu Shua, Zhu Yongmeib, Wang Taoa, Luo Jina,b   

  1. a. Jiangxi Province Key Laboratory of Chemical Biology, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022;
    b. Analytical & Testing Center, Jiangxi Normal University, Nanchang 330022
  • Received:2019-12-19 Revised:2017-02-19 Published:2017-03-03
  • Contact: 10.6023/cjoc201612048;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.21262018,21562026) and the Natural Science Foundation of Jiangxi Province (Nos.20161BAB203085,20161BAB213072).

In an attempt to discover novel fuse heterocyclic compound with high herbicidal activity, sixteen newly 2-alkythio-thieno[2,3-d]pyrimidin-4(3H)-ones have been designed and synthesized by the reaction of 3-propyl-6-ethylthieno[2,3-d]pyrimidine-2-thione with halo-hydrocarbon. Their structures were clearly verified by 1H NMR, IR, LC-MS and elemental analysis. Preliminary bioassay results indicate that some target compounds have excellent inhibitory activities on barnyard grass and rape. 2-Cyclopentylthio-3-n-propyl-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one (4e) and 2-n-hexdecylthio-3-n-propyl-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one (4o) show 100% inhibition rate to barnyard grass at the concentration of 100 mg/L.

Key words: thieno[2,3-d]pyrimidin-4(3H)-ones, synthesis, herbicidal activitiess