Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (9): 2250-2262.DOI: 10.6023/cjoc201704031 Previous Articles     Next Articles

Special Issue: 热点论文合辑



吴正兴, 张万斌   

  1. 上海交通大学化学化工学院 上海 200240
  • 收稿日期:2017-04-18 修回日期:2017-05-22 发布日期:2017-05-25
  • 通讯作者: 张万斌
  • 基金资助:


Recent Advances in Metal-Catalyzed 1,2-Difunctionalization of Conjugated Dienes

Wu Zhengxing, Zhang Wanbin   

  1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240
  • Received:2017-04-18 Revised:2017-05-22 Published:2017-05-25
  • Contact: 10.6023/cjoc201704031
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21232004, 21672142), the Program of Shanghai Subject Chief Scientists (No. 14XD1402300) and the Basic Research Foundation of Shanghai Science and Technology Committee (No. 15JC1402200).

The 1,2-difunctionalization of conjugated dienes is an important homogeneous catalytic reaction. The obtained products through 1,2-difunctionalization are widely existed in natural products and bioactive compounds, and are also sources of important organic intermediates, in addition, the preserved double bond in the difunctionalized product can be further transformed to give the desired structures or be functionalized sequentially to achieve multi-functionalization. The main difficulties focus on the encountered complex selectivities, including the regioselectivity, chemoselectivity and stereoselectivity in reactions. In recent years, with the development of organometallic chemistry, metal palladium, copper, iron or silver catalyzed 1,2-difunctionalizations of conjugated dienes have been reported in succession. In some cases the enantioselective 1,2-difunctionalizations of conjugated dienes were achieved via the introduction of chiral ligands. This review mainly focus on the recent metal catalyzed 1,2-difunctionalizations of conjugated dienes.

Key words: metal-catalyzed, conjugated diene, 1,2-difunctionalization