Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (3): 642-647.DOI: 10.6023/cjoc201708028 Previous Articles     Next Articles

Special Issue: 碳氢活化合辑2018-2019



王黎明, 林赓, 赵美君, 刘东垚, 金瑛   

  1. 吉林医药学院 药学院 吉林 132013
  • 收稿日期:2017-08-15 修回日期:2017-10-15 发布日期:2017-11-17
  • 通讯作者: 金瑛,
  • 基金资助:


Chiral Urea Derivatives Organocatalyzed Asymmetric aza-Friedel-Crafts Reaction of α-Naphthol with N-Tosyl Aldimines

Wang Liming, Lin Geng, Zhao Meijun, Liu Dongyao, Jin Ying   

  1. Department of Pharmacy, Jilin Medical University, Jilin 132013
  • Received:2017-08-15 Revised:2017-10-15 Published:2017-11-17
  • Contact: 10.6023/cjoc201708028
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21102055), the Department of Education of Jilin Province (No. JJKH20170409KJ) and the National Students' Program for Innovation and Entrepreneurship Training (No. 201713743010).

Chiral urea derivatives as organocatalysts were applied in the asymmetric aza-Friedel-Crafts reaction of α-naphthol with 14 N-tosyl aldimines. The desired chiral aminoarylnaphthols were obtained in 70%~86% yields with up to 78% enantiomeric excess (ee) under the screened optimal condition. The catalyst type and the substrate scope were broadened in this methodology.

Key words: chiral urea derivatives, asymmetric catalysis, α-naphthol, aza-Friedel-Crafts reaction