Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (4): 963-968.DOI: 10.6023/cjoc201710027 Previous Articles     Next Articles



陈震a, 郭康b, 陈荣顺b, 顾晨b, 周华婷b, 朱映光b   

  1. a 泰山医学院化学与制药工程学院 泰安 271016;
    b 南京农业大学理学院化学系 江苏省农药学重点实验室 南京 210095
  • 收稿日期:2017-10-23 修回日期:2017-12-01 发布日期:2017-12-08
  • 通讯作者: 陈荣顺, 朱映光;
  • 基金资助:


Facile Access to β-Ketosulfones via Mn-Mediated Reductive Coupling of α-Bromoketones with Sulfonyl Chlorides

Chen Zhena, Guo Kangb, Chen Rongshunb, Gu Chenb, Zhou Huatingb, Zhu Yingguangb   

  1. a School of Chemistry and Pharmaceutical Engineering, Taishan Medical University, Tai'an 271016;
    b Jiangsu Key Laboratory of Pesticide Science and Department of Chemistry, College of Sciences, Nanjing Agricultural University, Nanjing 210095
  • Received:2017-10-23 Revised:2017-12-01 Published:2017-12-08
  • Contact: 10.6023/cjoc201710027;
  • Supported by:

    Project supported by the Natural Science Foundation of Jiangsu Province (No. BK20150652), the National Natural Science Foundation of China (No. 21502096), the Fundamental Research Funds for the Central Universities (No. KJQN201629), and "333 High Level Talent Project" of Jiangsu Province.

A mild and highly efficient reductive coupling of α-bromoketones with sulfonyl chlorides is described. Various β-ketosulfones can be obtained under mild conditions in good to excellent yields. This method provides a simple and practical access to β-ketosulfones and is amenable to gram scale with no special precautions to exclude air or moisture.

Key words: β-ketosulfones, α-bromoketones, sulfonyl chlorides, reductive coupling, manganese