Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (5): 1193-1198.DOI: 10.6023/cjoc201710035 Previous Articles     Next Articles



肖祯a,b, 乐强a,b, 冉子垚a,b, 张谦a,b, 李栋b   

  1. a 湖北省太阳能高效利用协同创新中心 武汉 430068;
    b 湖北工业大学材料与化学工程学院 武汉 430068
  • 收稿日期:2017-10-27 修回日期:2017-12-23 发布日期:2018-01-10
  • 通讯作者: 张谦,;李栋,;
  • 基金资助:


Copper-Promoted N-Arylation of 8-Acylaminoquinoline Compounds

Xiao Zhena,b, Yue Qianga,b, Ran Ziyaoa,b, Zhang Qiana,b, Li Dongb   

  1. a Hubei Collaborative Innovation Center for High-efficiency Utilization of Solar Energy, Wuhan 430068;
    b College of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068
  • Received:2017-10-27 Revised:2017-12-23 Published:2018-01-10
  • Contact: 10.6023/cjoc201710035;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21702054) and the Open Fund of Hubei Collaborative Innovation Center for High-efficiency Utilization of Solar Energy (No. HBSKFQN2016003).

A copper-promoted N-arylation of 8-acylaminoquinolines has been developed. The N-arylation of 8-acylaminoquinoline with triaryl bismuth generated the target products in moderate to high yields under 40 mol% Cu(OAc)2, 2.0 equiv. of NaHCO3 in 1, 4-dioxane at 100 ℃ for 12 h. The reaction is compatible with a wide range of quinoline substrates, which provides a new method for synthesis of N-arylamide compounds.

Key words: copper, arylation, 8-acylaminoquinoline, triaryl bismuth