Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (5): 1199-1206.DOI: 10.6023/cjoc201711011 Previous Articles     Next Articles



仲帅帅, 黄鹏, 王兴越, 林觅, 葛春华   

  1. 辽宁大学化学院 沈阳 110036
  • 收稿日期:2017-11-07 修回日期:2017-12-25 发布日期:2018-01-10
  • 通讯作者: 黄鹏,;葛春华,;
  • 基金资助:


Synthesis of Quinoline-2, 4-diones from Cyanoacetanilide Derivatives

Zhong Shuaishuai, Huang Peng, Wang Xingyue, Lin Mi, Ge Chunhua   

  1. College of Chemistry, Liaoning University, Shenyang 110036
  • Received:2017-11-07 Revised:2017-12-25 Published:2018-01-10
  • Contact: 10.6023/cjoc201711011;
  • Supported by:

    Project supported by the Doctoral Scientific Research Foundation of Liaoning Province (No. 201601096) and the Science and Technology Plan Project of Shenyang City (No. F17-231-1-05).

Quinoline-2, 4-dione unit is present in many natural products and synthetic compounds along with a broad range of bioactivities. Herein, a new approach to the synthesis of quinoline-2, 4-diones is developed based on a methyl triflate (TfOMe)-promoted intramolecular Houben-Hoesch reaction of α, α-dialkyl substituted cyanoacetanilides. The broad substrate scope, simple operation and mild reaction conditions make this synthetic method very attractive.

Key words: quinolinone, nitrile, methylation, cyclization