Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (6): 1350-1363.DOI: 10.6023/cjoc201801017 Previous Articles     Next Articles

Special Issue: 有机光催化合辑

Reviews

胺-胺氧化偶联合成亚胺的研究进展

刘迪, 张成慧, 韩楠, 杜萌萌, 张效露, 赵朋杉, 杨萍   

  1. 山东科技大学化学与环境工程学院 青岛 266590
  • 收稿日期:2018-01-09 修回日期:2018-02-09 发布日期:2018-02-11
  • 通讯作者: 刘迪,E-mail:ld002037132@163.com E-mail:ld002037132@163.com
  • 基金资助:

    海藻活性物质国家重点实验室开放基金(No.SKL-BASS1723)资助项目.

Progress in Oxidative Coupling of Amines to Imines

Liu Di, Zhang Chenghui, Han Nan, Du Mengmeng, Zhang Xiaolu, Zhao Pengshan, Yang Ping   

  1. College of Chemical and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590
  • Received:2018-01-09 Revised:2018-02-09 Published:2018-02-11
  • Contact: 10.6023/cjoc201801017 E-mail:ld002037132@163.com
  • Supported by:

    Project supported by the Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances (No. SKL-BASS1723).

Imines are a class of active intermediates and have good antibacterial activity, therefore, they have received the extensive concern of scientists. Since the preparation method of imines by oxidative coupling of amines has the advantages of high atom economy and environmental friendliness, it has become a research hotspot. The recent progress in oxidative coupling of amines to imines is summarized from two aspects:catalyst and catalytic mechanism in this article. We introduced all kinds of catalytic systems in detail such as noble metal, non-noble metal, photocatalysis, biomimetic catalysis, poly aniline, graphite oxide, and azobisisobutyronitrile (AIBN). The catalytic performance, advantages and drawbacks and applicability of which are highlighted. And the catalytic mechanisms of the main catalytic systems are also discussed. It should be pointed out that these catalytic systems for oxidative coupling of amines to imines showed varying degrees of success as well as limitations like high cost of catalyst, harsh reaction condition, use of oxidant, alkaline additives and/or toxic organic solvents. Finally, based on the existential problems for oxidative coupling of amines to imines, the research directions in this field are predicted.

Key words: amines, oxidation coupling, imines, transition-metal catalysis, photocatalysis, biomimetic catalysis