Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (7): 1608-1625.DOI: 10.6023/cjoc201803005 Previous Articles     Next Articles

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Halo-Michael/Aldol串联反应及其在合成中的应用

代义华a, 申艳芳a, 高栓虎a,b   

  1. a 华东师范大学化学与分子工程学院 上海绿色化学与化工工程绿色化重点实验室 上海 200062;
    b 华东师范大学 上海分子治疗与新药创制工程技术研究中心 上海 200062
  • 收稿日期:2018-03-04 修回日期:2018-04-02 出版日期:2018-07-25 发布日期:2018-04-04
  • 通讯作者: 高栓虎 E-mail:shgao@chem.ecnu.edu.cn
  • 基金资助:

    国家自然科学基金(No.21772044)、上海市优秀学术带头人计划(No.18XD1401500)、青年拔尖人才项目及中央高校基本科研业务费.

Cascade Halo-Michael/Aldol Reaction and Its Application in Synthesis

Dai Yihuaa, Shen Yanfanga, Gao Shuanhua,b   

  1. a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062;
    b Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062
  • Received:2018-03-04 Revised:2018-04-02 Online:2018-07-25 Published:2018-04-04
  • Contact: 10.6023/cjoc201803005 E-mail:shgao@chem.ecnu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21772044), the Program of Shanghai Academic/Technology Research Leader (No. 18XD1401500), the National Young Top-Notch Talent Support Program and the Fundamental Research Funds for the Central Universities.

Michael addition and aldol reaction are among the most basic and commoly used reactions. Cascade halo-Michael/Aldol reaction can effectively improve the atomic economy and step economy of organic synthesis. After the Michael addition of α,β-unsaturated compound with halide ion (Cl-, Br-, I-), the reactive intermediate reacts with aldehyde through aldol reaction in the same reaction system. This process is called cascade halo-Michael/Aldol reaction. The cascade halo-Michael/Aldol reaction and its applications in the synthesis of related compounds according to the types of Lewis acid are introduced.

Key words: halo-michael/aldol reaction, cascade reaction, Lewis acid, application, synthesis