Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (12): 3296-3301.DOI: 10.6023/cjoc201805019 Previous Articles     Next Articles



胡昕宇, 杨伯斌, 姚玮, 王大伟   

  1. 江南大学化学与材料工程学院 教育部合成与生物胶体重点实验室 无锡 214122
  • 收稿日期:2018-05-08 修回日期:2018-07-18 发布日期:2018-08-14
  • 通讯作者: 王大伟
  • 基金资助:


Alanine Triazole Mn-Catalyzed Coupling/Aromatization of Quinone Methides

Hu Xinyu, Yang Bobin, Yao Wei, Wang Dawei   

  1. Key Laboratory of Synthetic and Biological Colloid, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122
  • Received:2018-05-08 Revised:2018-07-18 Published:2018-08-14
  • Contact: 10.6023/cjoc201805019
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 2176111), the Fundamental Research Funds for the Central Universities (No. JUSRP 51627B).

Alanine triazole Mn-catalyzed 1,6-conjugate coupling/aromatization of para-quinone methides was developed with good to high yields under mild conditions. This protocol provided an efficient and practical route to the synthetically interesting functionalized methines and their analogues. Preliminary mechanistic experiments revealed 1,6-conjugate addition of nucleophiles to para-quinone methides (p-QMs). The manganese was acted as the Lewis acid.

Key words: quinone methide, manganese, ligand, triazole