Synthesis and Insecticidal Activity of Novel 4-Arylamino Pyrimidine Derivatives

doi:10.6023/cjoc201807044

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (3): 852-860.DOI: 10.6023/cjoc201807044 Previous Articles Next Articles

Notes

新型4-芳氨基嘧啶类衍生物的合成及其杀虫活性

吴宁捷^a, 程龙^b, 王剑^b, 郁季平^a, 邢家华^a, 许天明^a, 魏优昌^a,b

a 中化蓝天浙江省化工研究院有限公司杭州 310023;
b 浙江工业大学化学工程学院杭州 310014

收稿日期:2018-07-24 修回日期:2018-10-22 发布日期:2018-11-26
通讯作者: 魏优昌 E-mail:weiyouchang@sinochem.com
基金资助:
中国博士后科学基金（No.2016M601971）资助项目.

Synthesis and Insecticidal Activity of Novel 4-Arylamino Pyrimidine Derivatives

Wu Ningjie^a, Cheng Long^b, Wang Jian^b, Yu Jiping^a, Xing Jiahua^a, Xu Tianming^a, Wei Youchang^a,b

a Sinochem Lantian Zhejiang Research Institute of Chemical Industry Co. Ltd., Hangzhou 310023;
b College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014

Received:2018-07-24 Revised:2018-10-22 Published:2018-11-26
Contact: 10.6023/cjoc201807044 E-mail:weiyouchang@sinochem.com
Supported by:
Project supported by the China Postdoctoral Science Foundation (No. 2016M601971).

1. Synthesis and Insecticidal Activity of Novel 4-Arylamino Pyrimidine Derivatives.PDF(4225KB)

Abstract

A series of novel 4-arylamino pyrimidine derivatives were synthesized using substituted aniline as starting material via diazotization, Meerwein arylation, isothiocyanation, addition, methylation and cyclization. The preliminary results of insecticidal activities indicated that most of the compounds exhibited 100% insecticidal activitiy against Mythimna separata Walker at 500 mg/L. At 20 mg/L, N-(2-chloro-4-fluorophenyl) -2,6-dimethyl-5-(4-phenoxy-2-(trifluoromethyl) phenyl) -pyrimidin-4-amine (6h) exhibited 80% and 60% mortality against Mythimna separata Walker and Plutella xylostella Linnaeus, respectively.

Key words: 4-arylamino pyrimidine, pyrimidinamine, synthesis, insecticidal

Cite this article

Wu Ningjie, Cheng Long, Wang Jian, Yu Jiping, Xing Jiahua, Xu Tianming, Wei Youchang. Synthesis and Insecticidal Activity of Novel 4-Arylamino Pyrimidine Derivatives[J]. Chin. J. Org. Chem., 2019, 39(3): 852-860.

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新型4-芳氨基嘧啶类衍生物的合成及其杀虫活性

Synthesis and Insecticidal Activity of Novel 4-Arylamino Pyrimidine Derivatives

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