Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (3): 852-860.DOI: 10.6023/cjoc201807044 Previous Articles     Next Articles



吴宁捷a, 程龙b, 王剑b, 郁季平a, 邢家华a, 许天明a, 魏优昌a,b   

  1. a 中化蓝天浙江省化工研究院有限公司 杭州 310023;
    b 浙江工业大学化学工程学院 杭州 310014
  • 收稿日期:2018-07-24 修回日期:2018-10-22 发布日期:2018-11-26
  • 通讯作者: 魏优昌
  • 基金资助:


Synthesis and Insecticidal Activity of Novel 4-Arylamino Pyrimidine Derivatives

Wu Ningjiea, Cheng Longb, Wang Jianb, Yu Jipinga, Xing Jiahuaa, Xu Tianminga, Wei Youchanga,b   

  1. a Sinochem Lantian Zhejiang Research Institute of Chemical Industry Co. Ltd., Hangzhou 310023;
    b College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2018-07-24 Revised:2018-10-22 Published:2018-11-26
  • Contact: 10.6023/cjoc201807044
  • Supported by:

    Project supported by the China Postdoctoral Science Foundation (No. 2016M601971).

A series of novel 4-arylamino pyrimidine derivatives were synthesized using substituted aniline as starting material via diazotization, Meerwein arylation, isothiocyanation, addition, methylation and cyclization. The preliminary results of insecticidal activities indicated that most of the compounds exhibited 100% insecticidal activitiy against Mythimna separata Walker at 500 mg/L. At 20 mg/L, N-(2-chloro-4-fluorophenyl) -2,6-dimethyl-5-(4-phenoxy-2-(trifluoromethyl) phenyl) -pyrimidin-4-amine (6h) exhibited 80% and 60% mortality against Mythimna separata Walker and Plutella xylostella Linnaeus, respectively.

Key words: 4-arylamino pyrimidine, pyrimidinamine, synthesis, insecticidal