Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (7): 1913-1922.DOI: 10.6023/cjoc201810037 Previous Articles     Next Articles



杨扬a, 郭举a, 刘站柱b   

  1. a 武汉工程大学绿色化工过程教育部重点实验室 武汉 430205;
    b 中国医学科学院/北京协和医学院药物研究所 北京 100050
  • 收稿日期:2018-10-30 修回日期:2019-01-25 发布日期:2019-03-29
  • 通讯作者: 郭举, 刘站柱;
  • 基金资助:


Progress in the Synthesis of Analogues of Bistetrahdro-isoquinoline Antitumor Alkaloids

Yang Yanga, Guo Jua, Liu Zhanzhub   

  1. a Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430205;
    b Institute of Materia Medica, China Academy of Medical Sciences & Peking Union Medical College, Beijing 100050
  • Received:2018-10-30 Revised:2019-01-25 Published:2019-03-29
  • Contact: 10.6023/cjoc201810037;
  • Supported by:

    Project supported by the Research Fund Project of Wuhan Institute of Technology (No. K201440), the Pilot Program of Scientific Research Project of Hubei Provincial Department of Education (No. B2016057), the Open Fund of Key Laboratory of New Reactor and Green Chemical Technology of Hubei Provincial (No. 201704).

Since the first tetrahydroisoquinoline alkaloid (THIQ), naphthyridinomycin, was found by Canadian scientist Kluepfel in 1974, nearly hundred members of this family have been reported. Such THIQ has attracted the research interest of many chemists and biologists due to its excellent biological activity and complex chemical structure. Especially, as an outstanding member of THIQ family, Ecteinascidin 743 (ET-743) has been commercialized in the European Union for the treatment of soft tissue tumors and ovarian cancer. Due to the extremely low content of natural products of bistetrahydroisoquinoline including ET-743 and the complexity of its chemical structure, the modification of its chemical structure has attracted more and more attention. Based on this, the recent advance in the synthesis of bistetrahydroisoquinoline analogues is reviewed.

Key words: antitumor activity, bistetrahydroisoquinoline alkaloid, analogue, research progress