Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (4): 1050-1054.DOI: 10.6023/cjoc201908005 Previous Articles     Next Articles


曹雪丽a, 郭晓b   

  1. a 泰山学院化学化工学院 山东泰安 271000;
    b 山东京卫制药有限公司 山东泰安 271000
  • 收稿日期:2019-08-03 修回日期:2019-10-24 发布日期:2020-05-06
  • 通讯作者: 郭晓
  • 基金资助:

A New Method for the Synthesis of 1,3,4-Thiadiazine Derivatives

Cao Xuelia, Guo Xiaob   

  1. a College of Chemistry and Chemical Engineering, Taishan University, Taian, Shandong 271000;
    b Jewim Pharmaceutical(Shandong) Co., Ltd, Taian, Shandong 271000
  • Received:2019-08-03 Revised:2019-10-24 Published:2020-05-06
  • Supported by:
    Project supported by the Research Foundation for Talented Scholars of Taishan University (No. 5002353).

An efficient method for the preparation of 1,3,4-thiadiazine derivatives has been reported. With 2,5-dihydroxy-1,4-dithiane and α-chloroindole containing different substituents, 13 compounds were synthesized. The yields of the compounds were above 82% except (E)-4-phenyl-2-styryl-5,6-dihydro-4H-1,3,4-thiadiazin-5-ol (3m). Furthermore, the proposed reaction mechanism was discussed. The developed method features simple operation, mild reaction condition, environmentally friendly, high yield and a broad range of substrate applicability. It provides a new way for the synthesis of 1,3,4-thiadiazine derivatives.

Key words: α-chloroindole, 1,3,4-thiadiazine, synthesis