Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (5): 1331-1336.DOI: 10.6023/cjoc201911010 Previous Articles     Next Articles


兰金, 谢宗波, 杨江楠, 孟佳, 刘一帅, 乐长高   

  1. 东华理工大学应用化学系 南昌 330013
  • 收稿日期:2019-11-06 修回日期:2019-12-19 发布日期:2020-01-21
  • 通讯作者: 谢宗波, 乐长高;
  • 基金资助:

One-Pot Multi-component Synthesis of N,O-Acetal Compounds Catalyzed by D-Proline at Room Temperature

Lan Jin, Xie Zongbo, Yang Jiangnan, Meng Jia, Liu Yishuai, Le Zhanggao   

  1. Department of Applied Chemistry, East China University of Technology, Nanchang 330013
  • Received:2019-11-06 Revised:2019-12-19 Published:2020-01-21
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21462001, 11765002), the Science and Technology Projects of Jiangxi Province (No. 20161BCB24006), and the Science and Technology Foundation of Jiangxi Provincial Department of Education (Nos. KJLD14050, GJJ150584).

In this paper, a convenient method for multi-component one-pot synthesis of N,O-acetal compounds was developed, using aromatic aldehyde, urea and alcohol as materials, alcohol also as solvent and D-proline as catalyst. A series of N,O-acetal compounds were synthesized in good yields after reacting for 30 h at room temperature.

Key words: D-proline, N,O-acetal compounds, one-pot synthesis, room temperature