Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (8): 2139-2144.DOI: 10.6023/cjoc201701003 Previous Articles     Next Articles



阮鸿力a, 张婧圆a, 孙赛a, 杨颖a, 朱小磊b, 吕成伟a   

  1. a 辽宁师范大学化学化工学院 大连 116029;
    b 鞍山市教师进修学校 鞍山 14000
  • 收稿日期:2017-01-05 修回日期:2017-03-21 发布日期:2017-04-18
  • 通讯作者: 吕成伟
  • 基金资助:


N-Bromosuccinimide Mediated the Reaction of 2-Hydroxyaryl Aldehydes with Meldrum's Acid for Synthesis of Coumarin-3-carboxylic Acids

Ruan Honglia, Zhang Jingyuana, Sun Saia, Yang Yinga, Zhu Xiaoleib, Lü Chengweia   

  1. a School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029;
    b Teachers Training College of Anshan, Anshan 114000
  • Received:2017-01-05 Revised:2017-03-21 Published:2017-04-18
  • Contact: 10.6023/cjoc201701003
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21403100) and the Doctoral Scientific Research Foundation of Liaoning Province (No. 20141100).

A N-bromosuccinimide (NBS) promoted procedure for the synthesis of coumarin-3-carboxylic acids via Knoevenagel-intramolecular cyclization cascade reaction of Meldrum's acid with various 2-hydroxyarylaldehydes has been developed. Using the mixture of water and ethanol as solvent, employing inexpensive NBS as the catalyst, and reacted at room temperature are found to highly applicable to get a satisfactory outcome. This approach expands the method for the preparation of coumarin-3-carboxylic acids and also provides other features such as mild reaction conditions, tolerant the substrates with diverse functional groups, simple workup procedure and easy isolation.

Key words: N-bromosuccinimide, coumarin-33-carboxylic acids, synthetic methods, room temperature, green chemistry