Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 1891-1900.DOI: 10.6023/cjoc202003019 Previous Articles     Next Articles


郑茜茜, 刘云云, 万结平   

  1. 江西师范大学化学化工学院 南昌 330022
  • 收稿日期:2020-03-08 修回日期:2020-04-01 发布日期:2020-04-13
  • 通讯作者: 刘云云, 万结平;
  • 基金资助:

Advances in the Synthesis of N-Sulfonyl Amidines

Zheng Xixi, Liu Yunyun, Wan Jie-Ping   

  1. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022
  • Received:2020-03-08 Revised:2020-04-01 Published:2020-04-13
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21861019).

Due to the special gem-nitrogen structure, amidines are important compounds in the synthesis of nitrogen contaning products. As a class of featured amidines, the N-sulfonyl amidines are key intermediates in a number of pivatol organic syntheses, and thus ocuppy significant position in modern organic synthesis. In this context, the research advances on the synthesis of N-sulfonyl amidines are herein reviewed. Based on the key reaction features, the introduction covers the synthetic methods of enamination by tertiary enamine oxidation, amide activation, akyne-azide-amine three-component reaction, enamine carbon-carbon bond functionalization and other related reactions. It is expected that this review will provide guidelines for the reasearch work in related areas.

Key words: N-sulfonyl amidine, synthesis, amine oxidation, amide activation, three-component, enamine reaction