Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (12): 4249-4257.DOI: 10.6023/cjoc202008014 Previous Articles     Next Articles


郑丹丹, 倪亚丹, 钱程, 张敏, 张紫婵, 戴红, 周贝贝, 张莉芳   

  1. 南通大学化学化工学院 江苏南通 226019
  • 收稿日期:2020-08-10 修回日期:2020-09-01 发布日期:2020-09-09
  • 通讯作者: 戴红, 张莉芳;
  • 基金资助:

Synthesis and Biological Activities of Novel N-Pyridylpyrazole Amide Compounds Carrying Isoxazole Unit

Zheng Dandan, Ni Yadan, Qian Cheng, Zhang Min, Zhang Zichan, Dai Hong, Zhou Beibei, Zhang Lifang   

  1. College of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019
  • Received:2020-08-10 Revised:2020-09-01 Published:2020-09-09
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21372135) and the Science and Technology Project Fund of Nantong City (No. MS12019060).

A series of new N-pyridylpyrazole amides bearing substituted isoxazole moiety were designed and prepared based on chlorantraniliprole. These compounds were structurally determined through 1H NMR, 13C NMR and elemental analyses. Bioassay results displayed that all designed compounds showed a mortality rate of 100% towards Oriental armyworm at the dosage of 500 μg/mL. At the dosage of 100 μg/mL, the mortality rates of four compounds towards Oriental armyworm were 80%~100%. Two compounds had 40%~50% insecticidal activities towards Oriental armyworm at the concentration of 20 μg/mL. At the concentration of 500 μg/mL, five compounds demonstrated 90%~100% insecticidal activities against Aphis medicaginis. Moreover, at the dosage of 500 μg/mL, two compounds exhibited 70%~80% insecticidal activities against Tetranychus cinnabarinus.

Key words: isoxazole, N-pyridylpyrazole, synthesis, biological activity