Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (8): 2974-2989.DOI: 10.6023/cjoc202102032 Previous Articles     Next Articles



刘改枝*(), 李金鑫, 史礼君, 刘萌芽, 蔡邦荣*()   

  1. 河南中医药大学药学院 郑州 450046
  • 收稿日期:2021-02-19 修回日期:2021-03-17 发布日期:2021-05-14
  • 通讯作者: 刘改枝, 蔡邦荣
  • 基金资助:
    中国博士后科学基金面上(2020M682311); 河南中医药大学博士基金(00104311-2019-33); 河南省科技攻关(202102310514)

Advances in the Study of Structural Modification and Biological Activities of Ursolic Acid

Gaizhi Liu(), Jinxin Li, Lijun Shi, Mengya Liu, Bangrong Cai()   

  1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046
  • Received:2021-02-19 Revised:2021-03-17 Published:2021-05-14
  • Contact: Gaizhi Liu, Bangrong Cai
  • Supported by:
    National Natural Science Foundation of China Postdoctoral Science Foundation(2020M682311); Doctorʼs Fund of Henan University of Medicine(00104311-2019-33); Award for Science and Technology Tackling Key Problems Program of Henan Province(202102310514)

Ursolic acid (UA) belongs to a group of pentacyclic triterpenoids extracted from medicinal plants, fruits and vegetables. In recent years, the pharmacological action of ursolic acid has been widely studied. It has been reported that UA has a variety of pharmacological activities, including anti-cancer, anti-inflammation, anti-oxidation, anti-bacterial, anti-diabetes and so on. In spite of that UA shows the extensive therapeutic potential as a drug candidate, the poor water solubility and low bioavailability of UA limit its clinical application. To address these issue, large numbers of UA-based derivatives with enhanced activities and better physicochemical character have been developed by structural modification of its parent skeleton. In this paper, the research progress of the synthesized UA derivatives with therapeutic potential along with their biological activities is reviewed, which provides reference for further drug development using UA as a lead compound.

Key words: ursolic acid, structural modification, anti-tumor, anti-diabetic, anti-inflammatory, antiviral