Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (8): 3034-3049.DOI: 10.6023/cjoc202102043 Previous Articles     Next Articles

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电化学合成氨基酸类化合物的研究进展

王娜娜a, 徐敬成a, 梅海波a, Hiroki Moriwakib, Kunisuke Izawab, Vadim A. Soloshonokc,d,*(), 韩建林a,*()   

  1. a 南京林业大学化学工程学院 江苏省林业资源高效加工利用协调创新中心 林产化学与材料国际创新高地 南京 210037 中国
    b 浜理药品株式会社 大阪 533-0024 日本
    c 巴斯克大学有机化学学院 圣塞巴斯蒂安 20018 西班牙
    d 巴斯克IKERBASQUE科学基金会 毕尔巴鄂 48011 西班牙
  • 收稿日期:2021-02-23 修回日期:2021-04-07 发布日期:2021-04-25
  • 通讯作者: Vadim A. Soloshonok, 韩建林
  • 基金资助:
    国家自然科学基金(21761132021)

Electrochemical Approaches for Preparation of Tailor-Made Amino Acids

Nana Wanga, Jingcheng Xua, Haibo Meia, Hiroki Moriwakib, Kunisuke Izawab, Vadim A. Soloshonokc,d(), Jianlin Hana()   

  1. a Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
    b Hamari Chemical Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan
    c Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country, Paseo Manuel Lardizábal 3, 20018 San Sebastián, Spain
    d IKERBASQUE, Basque Foundation for Science, Alameda Urquijo 36-5, Plaza Bizkaia, 48011 Bilbao, Spain
  • Received:2021-02-23 Revised:2021-04-07 Published:2021-04-25
  • Contact: Vadim A. Soloshonok, Jianlin Han
  • Supported by:
    National Natural Science Foundation of China(21761132021)

Due to the pivotal role of tailor-made amino acids in modern medicinal chemistry research and drug design, the interest in the development of synthetic methodology for preparation of these compounds is at an all-time high. Currently, electrochemical approaches for synthesis of amino acids are being actively pursued to take the advantage of sustainability and green chemistry facets offered by the electrochemistry. This work presents the first specially focused, comprehensive treatment of the literature data related to synthesis of amino acids via electrochemical means. Aspects of practicality, benefits and current shortcoming of this approach are critically discussed.

Key words: electrochemical reactions, amino acids, radical reactions, asymmetric synthesis, Ni-complex