Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (12): 4623-4638.DOI: 10.6023/cjoc202106046 Previous Articles     Next Articles



周琨, 毛羊杰, 吴峰伟, 娄绍杰*(), 许丹倩*()   

  1. 浙江工业大学催化加氢研究中心 浙江省绿色农药清洁生产技术研究重点实验室 杭州 310014
  • 收稿日期:2021-06-24 修回日期:2021-08-10 发布日期:2021-08-24
  • 通讯作者: 娄绍杰, 许丹倩
  • 基金资助:

Recent Advances in C—H Bond Functionalization under Mechanochemical Conditions

Kun Zhou, Yangjie Mao, Fengwei Wu, Shaojie Lou(), Danqian Xu()   

  1. Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Catalytic Hydrogenation Research Center, Zhejiang University of Technology, Hangzhou 310014
  • Received:2021-06-24 Revised:2021-08-10 Published:2021-08-24
  • Contact: Shaojie Lou, Danqian Xu
  • Supported by:
    National Key Research and Development Program(2017YFB0307203)

Mechanochemistry has received increasing attention in the past decade. Among which, the mechanochemical C—H bond functionalization has emerged as a hot research topic. In comparison with the traditional solution-based organic reactions, the mechanochemical transformation features solvent-less conditions and short reaction time, constituting a green and efficient synthetic method in the modern chemical society. Notably, given the outstanding features, some long-standing challenges in the previous solution-based reactions could be well-solved by mechanochemical methods. Therefore, a timely comprehensive overview to recognize the present status of the mechanochemical C—H bond functionalization is of great importance to stimulate the development of more efficient synthetic methods. In this review, the state of the art for mechanochemical C—H bond transformation is presented. The limitation in this research field is also analyzed and the outlook of this area is prospected.

Key words: mechanochemistry, C—H bond functionalization, ball milling, solvent-free, green chemistry