Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (12): 4610-4622.DOI: 10.6023/cjoc202107042 Previous Articles     Next Articles

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电化学条件下喹喔啉-2(1H)-酮C(3)—H功能化的研究进展

李丹丹*(), 王晓辰, 李闪闪, 付晨雨, 李倩倩, 许东涛, 马莹莹   

  1. 许昌学院化工与材料学院 表面微纳米材料研究所 河南省储能与转化微纳米材料重点实验室 河南许昌 461000
  • 收稿日期:2021-07-18 修回日期:2021-09-04 发布日期:2021-09-14
  • 通讯作者: 李丹丹
  • 基金资助:
    国家自然科学基金(21901219); 河南教育厅重点项目(20B150024); 2021年度河南省高等教育青年骨干教师培养计划(2021GGJS146); 河南省药品质量控制与评价重点实验室(郑州大学)开放课题科研基金和许昌学院杰出青年骨干资助项目

Recent Advances in Electrochemical C(3)—H Functionalization of Quinoxalin-2(1H)-ones

Dandan Li(), Xiaochen Wang, Shanshan Li, Chenyu Fu, Qianqian Li, Dongtao Xu, Yingying Ma   

  1. Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Xuchang, Henan 461000
  • Received:2021-07-18 Revised:2021-09-04 Published:2021-09-14
  • Contact: Dandan Li
  • Supported by:
    National Natural Science Foundation of China(21901219); Key Project of Education Department of Henan Province(20B150024); Young Key Teacher Training Plan of Henan Provincial Higher Education in 2021(2021GGJS146); Open Subject Research Fund of the Key Laboratory of Drug Quality Control and Evaluation in Henan Province and the Young Backbone Teachers Project of Xuchang University

Quinoxalinone and its derivatives are a class of important nitrogen heterocyclic compounds, which widely exist in natural products, drugs and functional materials. Therefore, the C—H functionalization of quinoxalinone has attracted extensive attention of chemical workers. In recent years, electrochemical synthesis directly uses electron as a “clean reagent” to participate in redox reaction without additional redox reagent, which has the characteristics of mild reaction conditions and good atom economy. This method meets the requirements of green chemistry and sustainable development. With the in-depth study on the mechanism of electrochemical synthesis and the standardization of reaction equipment, this method has become a powerful tool for functionalization of quinoxalineones. The recent advances in the electrochemical C(3)—H functionalization of quinoxaline-2(1H)-one are summarized. The reaction transformation conditions and mechanisms are systematically discussed, and the challenges and future directions of this field are included.

Key words: electrochemical synthesis, quinoxalin-2(1H)-one, C(3)—H functionalization