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Streptomycessp.N12W1565中抑菌溴代naphthacemycin的表征

彭淑娅a,b, 路新华c, 花强*,a, 唐功利*,b   

  1. a华东理工大学生物工程学院 上海 200030;
    b中国科学院上海有机化学研究所 上海 200032;
    c微生物药物国家工程研究中心 石家庄 050015
  • 收稿日期:2025-12-25 修回日期:2026-01-13
  • 基金资助:
    国家自然科学基金(No. 22137009)资助项目.

Characterization of Antibacterial Bromo-naphthacemycin from Streptomyces sp. N12W1565

Peng Shu-Yaa,b, Lu Xin-Huac, Hua Qiang*,a, Tang Gong-Li*,b   

  1. aDepartment of Applied Biology, East China University of Science and Technology, Shanghai 200030;
    bShanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
    cNational Microbial Medicine Engineering and Research Center, Shijiazhuang 050015
  • Received:2025-12-25 Revised:2026-01-13
  • Contact: *E-mail: gltang@sioc.ac.cn; qhua@ecust.edu.cn
  • Supported by:
    National Natural Science Foundation of China (No. 22137009).

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Supporting Info.

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The halogenated natural product naphthacemycin was isolated from Streptomyces sp. N12W1565 strain associated with the stems of the traditional Chinese medicinal herb Senecio scandens Buch.-Ham. Ex D. Don. Previous studies have established that polychlorination of this metabolite was catalyzed by the multi-site halogenase NatC encoded within the naphthacemycin biosynthetic gene cluster, suggesting that modulation of halide species in the culture medium can enable the generation of diverse halogenated analogues. In this study, brominated naphthacemycins were produced by optimizing the fermentation conditions of this strain. Three novel monobrominated naphthacemycins were successfully characterized by high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and nuclear magnetic resonance (NMR) spectroscopy, among which compound 5 and 7 exhibited significantly enhanced antibacterial activity compared to the non-brominated compound 1.

Key words: type II polyketides natural product, naphthacemycin, halogenation, antibacterial